PRPF31 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000210
Fusion event
HBV-PRPF31 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1802
Integrated sequence
GCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCT| |GCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGC
Host Sequence
Chromosome
chr11
Cytoband
q21
Reference genome
GRCh38.p7
Start
94712026 (Hg38)
End
94712026 (Hg38)
Orient
-
Location type
Intronic
Target gene
PRPF31
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-383-3p
Nearest miRNA
hsa-mir-10392/Upstream/245446; hsa-let-7a-2/Downstream/1629412;
Nearest TSS
ENST00000527297/Upstream/5595; ENST00000539727/Downstream/28243;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/166279, chr11-CpG: 83/Downstream/28343
Downstream sequence
TACTAGGAGGCTGTAGGCATAAATTGGTCT
Junction sequence
AACATTAATAGTTTGAAGTTTCTTTTAAACTACTAGGAGGCTGTAGGCATAAATTGGTCT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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