HTR3B _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000211
Fusion event
HBV-HTR3B integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1887
Integrated sequence
GGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTT| |GGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAG
Host Sequence
Chromosome
chr11
Cytoband
q23.2
Reference genome
GRCh38.p7
Start
113903449 (Hg38)
End
113903449 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11G
Target gene
HTR3B
miRNAs that regulate target gene
hsa-mir-4699-3p
Nearest miRNA
hsa-mir-10392/Upstream/453361; hsa-let-7a-2/Downstream/4740551;
Nearest TSS
ENST00000527297/Upstream/27879; ENST00000543092/Downstream/1228;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/27478, chr11-CpG: 33/Downstream/132749
Nearby gene
USP28(-27879) ; HTR3B(+1228) ;
Downstream sequence
CCTACTGTTCAAGCCTCCAAGCTGTGCCTT
Junction sequence
AGGCGGAGTCTCCCTCTGTCTCCCAGGCTGCCTACTGTTCAAGCCTCCAAGCTGTGCCTT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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