Basic Information
VIS ID
TVIS10000213
Fusion event
HBV-chr12 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1829
Integrated sequence
GACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCA| |CCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTT
Host Sequence
Chromosome
chr12
Cytoband
p11.1
Reference genome
GRCh38.p7
Start
34377963 (Hg38)
End
34377963 (Hg38)
Orient
+
Nearest miRNA
hsa-mir-1244-3/Upstream/8503884; hsa-let-7i/Downstream/7945737;
Nearest TSS
ENST00000382841/Upstream/159110; ENST00000553138/Downstream/3938615;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/27284, chr12-CpG: 44/Downstream/3760263
Nearby gene
PRPF31(-159110) ;
Downstream sequence
TCTGCGCACCAGCACCATGCAACTTTTTCA
Junction sequence
AATAGGCCCTCTGTGGGCATGAACGAGGGATCTGCGCACCAGCACCATGCAACTTTTTCA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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