PRPF31 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000215
Fusion event
HBV-PRPF31 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1826
Integrated sequence
AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT| |TCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAA
Host Sequence
Chromosome
chr12
Cytoband
q21.32
Reference genome
GRCh38.p7
Start
86660218 (Hg38)
End
86660218 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12B
Target gene
PRPF31
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-383-3p
Nearest miRNA
hsa-let-7i/Upstream/5501757; hsa-mir-1178/Downstream/84850;
Nearest TSS
ENST00000382841/Upstream/58914; ENST00000551280/Downstream/178667;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/1379296, chr12-CpG: 52/Downstream/1375110
Downstream sequence
TGGTCTGCGCACCAGCACCATGCAACTTTT
Junction sequence
TTAATGGCTCTACATCTATCAAAAGTATTATGGTCTGCGCACCAGCACCATGCAACTTTT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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