Basic Information
VIS ID
TVIS10000219
Fusion event
HBV-chr14 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1828
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr14
Cytoband
q12
Reference genome
GRCh38.p7
Start
29201494 (Hg38)
End
29201494 (Hg38)
Orient
-
Nearest miRNA
hsa-mir-208a/Upstream/1568216; hsa-mir-1185-1/Downstream/1813152;
Nearest TSS
ENST00000550708/Upstream/222570; ENST00000549515/Downstream/188852;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/415631, chr14-CpG: 147/Downstream/725510
Nearby gene
PRPF31(+62887) ;
Downstream sequence
TCTATCTTCTAATCTCTAGATGCCAGACTG
Junction sequence
GTCTGCGCACCAGCACCATGCAACTTTTTCTCTATCTTCTAATCTCTAGATGCCAGACTG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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