Basic Information
VIS ID
TVIS10000221
Fusion event
HBV-chr14 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1829
Integrated sequence
GACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCA| |CCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTT
Host Sequence
Chromosome
chr14
Cytoband
q24.1
Reference genome
GRCh38.p7
Start
69567036 (Hg38)
End
69567036 (Hg38)
Orient
+
Fragile sites / regions
FRA14C
Nearest miRNA
hsa-mir-208a/Upstream/2125106; hsa-mir-1185-1/Downstream/2949784;
Nearest TSS
ENST00000550708/Upstream/82282; ENST00000553497/Downstream/7801;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/18760, chr14-CpG: 339/Downstream/4355
Nearby gene
PLEKHD1(-35485) ; CCDC177(+2780) ;
Downstream sequence
TCTGCGCACCAGCACCATGCAACTTTTTCA
Junction sequence
AAGAAATACCAAGTTTCCTCATGTTCCTCTTCTGCGCACCAGCACCATGCAACTTTTTCA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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