Basic Information
VIS ID
TVIS10000225
Fusion event
HBV-LOC112268144 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1818
Integrated sequence
GTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATG| |CAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTT
Host Sequence
Chromosome
chr15
Cytoband
q15.1
Reference genome
GRCh38.p7
Start
40977792 (Hg38)
End
40977792 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC112268144
Nearest miRNA
hsa-mir-1233-1/Upstream/4004891; hsa-mir-10393/Downstream/713793;
Nearest TSS
ENST00000557528/Upstream/23586; ENST00000561388/Downstream/5427;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/23986, chr15-CpG: 80/Downstream/138069
Nearby gene
CHAC1(-21273) ; INO80(+1088) ;
Downstream sequence
GCATAAATTGGTCTGCGCACCAGCACCATG
Junction sequence
TTATATGCCCGCACCCCAGCCAGGAAGCCCGCATAAATTGGTCTGCGCACCAGCACCATG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
Curate