Basic Information
VIS ID
TVIS10000228
Fusion event
HBV-EFL1 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1827
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr15
Cytoband
q25.2
Reference genome
GRCh38.p7
Start
82138381 (Hg38)
End
82138381 (Hg38)
Orient
-
Location type
Intronic
Target gene
EFL1
miRNAs that regulate target gene
hsa-mir-30a-5p
Nearest miRNA
hsa-mir-10393/Upstream/1140908; hsa-mir-11181/Downstream/928954;
Nearest TSS
ENST00000557528/Upstream/49690; ENST00000562097/Downstream/21689;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/90785, chr15-CpG: 70/Downstream/124063
Downstream sequence
GGTCTGCGCACCAGCACCATGCAACTTTTT
Junction sequence
TTTAAGATGCTGAAAATTTAATCCTTTTTTGGTCTGCGCACCAGCACCATGCAACTTTTT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
Curate