Basic Information
VIS ID
TVIS10000230
Fusion event
HBV-chr16 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1815
Integrated sequence
ACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACC| |ATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACC
Host Sequence
Chromosome
chr16
Cytoband
p13.2
Reference genome
GRCh38.p7
Start
8488974 (Hg38)
End
8488974 (Hg38)
Orient
-
Nearest miRNA
hsa-mir-1225/Upstream/2856408; hsa-mir-11401/Downstream/2817466;
Nearest TSS
ENST00000527434/Upstream/119110; ENST00000563037/Downstream/43039;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/834886, chr16-CpG: 21/Downstream/80723
Nearby gene
PRPF31(-112698) ;
Downstream sequence
TAGGCATAAATTGGTCTGCGCACCAGCACC
Junction sequence
CCTCCCCCCTCCCTTCCTCCTCCACCCACCTAGGCATAAATTGGTCTGCGCACCAGCACC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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