Basic Information
VIS ID
TVIS10000232
Fusion event
HBV-chr16 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1728
Integrated sequence
CCCACCGAATGTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCTGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAA| |AGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC
Host Sequence
Chromosome
chr16
Cytoband
q11.2
Reference genome
GRCh38.p7
Start
46390441 (Hg38)
End
46390441 (Hg38)
Orient
-
Nearest miRNA
hsa-mir-1225/Upstream/12226768; hsa-mir-11401/Downstream/3902175;
Nearest TSS
ENST00000527434/Upstream/10603554; ENST00000569239/Downstream/193812;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/10287728, chr16-CpG: 124/Downstream/37017
Nearby gene
RNU6-845P(+165648) ;
Downstream sequence
TGAGGCATACTTCAAAGACTGTTTGTTTAA
Junction sequence
TCCATTTCGATTCCACTCGATGATGATTTCTGAGGCATACTTCAAAGACTGTTTGTTTAA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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