COG8 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000233
Fusion event
HBV-COG8 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1824
Integrated sequence
TTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAG
Host Sequence
Chromosome
chr16
Cytoband
q22.1
Reference genome
GRCh38.p7
Start
69335265 (Hg38)
End
69335265 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA16B
Target gene
COG8
miRNAs that regulate target gene
hsa-mir-186-5p
Nearest miRNA
hsa-mir-1225/Upstream/1101766; hsa-mir-11401/Downstream/230543;
Nearest TSS
ENST00000527434/Upstream/394; ENST00000562131/Downstream/3312;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/4333, chr16-CpG: 91/Downstream/3893
Downstream sequence
ATTGGTCTGCGCACCAGCACCATGCAACTT
Junction sequence
TGCCTGCCTCCGTGTCATTGGCTACCTGCGATTGGTCTGCGCACCAGCACCATGCAACTT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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