Basic Information
VIS ID
TVIS10000234
Fusion event
HBV-chr16 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1713
Integrated sequence
AGACCACCGTGAACGCCCACCGAATGTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCTGCAATGTCAACGACCGACCTTGAGGCATACTTCAA| |AGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCA
Host Sequence
Chromosome
chr16
Cytoband
q23.1
Reference genome
GRCh38.p7
Start
74140709 (Hg38)
End
74140709 (Hg38)
Orient
-
Nearest miRNA
hsa-mir-1225/Upstream/4110287; hsa-mir-11401/Downstream/2728227;
Nearest TSS
ENST00000527434/Upstream/120738; ENST00000561669/Downstream/41226;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/1073817, chr16-CpG: 74/Downstream/155926
Downstream sequence
GTCAACGACCGACCTTGAGGCATACTTCAA
Junction sequence
TTTCTGGGTTTTTTGGGCTATTATGAATAAGTCAACGACCGACCTTGAGGCATACTTCAA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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