Basic Information
VIS ID
TVIS10000235
Fusion event
HBV-chr16 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1714
Integrated sequence
GACCACCGTGAACGCCCACCGAATGTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCTGCAATGTCAACGACCGACCTTGAGGCATACTTCAAA| |GACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCAC
Host Sequence
Chromosome
chr16
Cytoband
q24.1
Reference genome
GRCh38.p7
Start
84280430 (Hg38)
End
84280430 (Hg38)
Orient
-
Nearest miRNA
hsa-mir-1225/Upstream/772022; hsa-mir-11401/Downstream/927366;
Nearest TSS
ENST00000527434/Upstream/19381; ENST00000613603/Downstream/14216;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/43179, chr16-CpG: 14/Downstream/14483
Nearby gene
RNA5SP433(-17502) ; WFDC1(+14216) ;
Nearest cancer related gene
WFDC1(TSG, +14216) ;
Downstream sequence
TCAACGACCGACCTTGAGGCATACTTCAAA
Junction sequence
GATCCCACCCAAACTGGATAAGAAACTCGGTCAACGACCGACCTTGAGGCATACTTCAAA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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