Basic Information
VIS ID
TVIS10000238
Fusion event
HBV-chr17 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1825
Integrated sequence
TAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTT| |TTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGA
Host Sequence
Chromosome
chr17
Cytoband
q21.2
Reference genome
GRCh38.p7
Start
42447617 (Hg38)
End
42447617 (Hg38)
Orient
-
Nearest miRNA
hsa-mir-1180/Upstream/930400; hsa-mir-10226/Downstream/47156;
Nearest TSS
ENST00000595228/Upstream/24100; ENST00000589213/Downstream/11227;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/24109, chr17-CpG: 24/Downstream/11111
Nearby gene
RNU7-97P(-7358) ; ATP6V0A1(+11227) ;
Downstream sequence
TTGGTCTGCGCACCAGCACCATGCAACTTT
Junction sequence
ACTCCCGACCTCAGGTGATCCGCCTGCCTTTTGGTCTGCGCACCAGCACCATGCAACTTT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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