Basic Information
VIS ID
TVIS10000244
Fusion event
HBV-chr19 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1812
Integrated sequence
AAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGC| |ACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCG
Host Sequence
Chromosome
chr19
Cytoband
p13.3
Reference genome
GRCh38.p7
Start
2285035 (Hg38)
End
2285035 (Hg38)
Orient
+
Fragile sites / regions
FRA19B
Nearest miRNA
hsa-mir-1227/Upstream/34317; hsa-let-7e/Downstream/149879;
Nearest TSS
ENST00000633603/Upstream/2859; ENST00000586111/Downstream/6989;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/6186, chr19-CpG: 237/Downstream/4861
Nearby gene
PEAK3(-2853) ; LINGO3(+4740) ;
Downstream sequence
CTGTAGGCATAAATTGGTCTGCGCACCAGC
Junction sequence
CAGCTGTCCTTTCATTTGAGAAGCCCTTATCTGTAGGCATAAATTGGTCTGCGCACCAGC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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