TMEM143 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000249
Fusion event
HBV-TMEM143 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1819
Integrated sequence
TTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGC| |AACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTA
Host Sequence
Chromosome
chr19
Cytoband
q13.33
Reference genome
GRCh38.p7
Start
48352423 (Hg38)
End
48352423 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
TMEM143
Nearest miRNA
hsa-mir-10395/Upstream/1125402; hsa-let-7e/Downstream/657483;
Nearest TSS
ENST00000633603/Upstream/9432; ENST00000600863/Downstream/11251;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/18131, chr19-CpG: 17/Downstream/10807
Downstream sequence
CATAAATTGGTCTGCGCACCAGCACCATGC
Junction sequence
GCTGAGGTAGGAGGATCGCTTGAGCCTGGGCATAAATTGGTCTGCGCACCAGCACCATGC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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