Basic Information
VIS ID
TVIS10000250
Fusion event
HBV-LOC105372460 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1825
Integrated sequence
TAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTT| |TTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGA
Host Sequence
Chromosome
chr19
Cytoband
q13.42
Reference genome
GRCh38.p7
Start
54517002 (Hg38)
End
54517002 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
LOC105372460
Nearest miRNA
hsa-let-7e/Upstream/234822; hsa-mir-10394/Downstream/128307;
Nearest TSS
ENST00000633603/Upstream/14095; ENST00000221567/Downstream/15690;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/45326, chr19-CpG: 25/Downstream/10022
Nearby gene
LAIR2(-6315) ; KIR3DX1(+15690) ;
Downstream sequence
TTGGTCTGCGCACCAGCACCATGCAACTTT
Junction sequence
ACTTTGCTACTTGCTCTACAAATACTATATTTGGTCTGCGCACCAGCACCATGCAACTTT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
Curate