Basic Information
VIS ID
TVIS10000253
Fusion event
HBV-chr20 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1917
Integrated sequence
GCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCT| |TATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATC
Host Sequence
Chromosome
chr20
Cytoband
p12.3
Reference genome
GRCh38.p7
Start
5680522 (Hg38)
End
5680522 (Hg38)
Orient
+
Nearest miRNA
hsa-mir-103a-2/Upstream/1762951; hsa-mir-1-1/Downstream/1691086;
Nearest TSS
ENST00000382410/Upstream/69496; ENST00000378979/Downstream/69871;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/69293, chr20-CpG: 57/Downstream/230710
Nearby gene
GPCPD1(-69496) ; SHLD1(+69871) ;
Downstream sequence
GGGTGGCTTTGGGGCATGGACATCGACCCT
Junction sequence
CCTGGGAAGGGACTCATGGATGAGTGAAAAGGGTGGCTTTGGGGCATGGACATCGACCCT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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