Basic Information
VIS ID
TVIS10000256
Fusion event
HBV-chr20 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1823
Integrated sequence
TTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACT| |TTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAA
Host Sequence
Chromosome
chr20
Cytoband
q13.2
Reference genome
GRCh38.p7
Start
54245435 (Hg38)
End
54245435 (Hg38)
Orient
-
Nearest miRNA
hsa-mir-103a-2/Upstream/176950; hsa-mir-1-1/Downstream/3076067;
Nearest TSS
ENST00000382410/Upstream/37007; ENST00000491469/Downstream/230162;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/36926, chr20-CpG: 96/Downstream/229759
Nearby gene
PFDN4(-17383) ;
Downstream sequence
AATTGGTCTGCGCACCAGCACCATGCAACT
Junction sequence
CTACACAGGGATTCATTATGGTATTATCTTAATTGGTCTGCGCACCAGCACCATGCAACT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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