Basic Information
VIS ID
TVIS10000257
Fusion event
HBV-chr20 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1680
Integrated sequence
GTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCGAATGTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCTGC| |AATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGA
Host Sequence
Chromosome
chr20
Cytoband
q13.33
Reference genome
GRCh38.p7
Start
62873222 (Hg38)
End
62873222 (Hg38)
Orient
+
Location type
Intronic
Target gene
ARF4P2 ; LOC105372717
Nearest miRNA
hsa-mir-1-1/Upstream/308209; hsa-mir-124-3/Downstream/305278;
Nearest TSS
ENST00000382410/Upstream/11459; ENST00000497101/Downstream/41184;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/10948, chr20-CpG: 22/Downstream/3841
Nearby gene
TCFL5(-11459) ; DIDO1(+4516) ;
Downstream sequence
CTTACATAAGAGGACTCTTGGACTCTCTGC
Junction sequence
CTCCCTGGCCCATGTGCTGGTGAAGCTGTACTTACATAAGAGGACTCTTGGACTCTCTGC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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