Basic Information
VIS ID
TVIS10000258
Fusion event
HBV-chr21 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1801
Integrated sequence
GGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTC| |TGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGG
Host Sequence
Chromosome
chr21
Cytoband
q21.1
Reference genome
GRCh38.p7
Start
20515553 (Hg38)
End
20515553 (Hg38)
Orient
+
Nearest miRNA
hsa-let-7c/Upstream/1829389; hsa-mir-155/Downstream/2563731;
Nearest TSS
ENST00000624081/Upstream/256733; ENST00000486367/Downstream/287510;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/2269996, chr21-CpG: 89/Downstream/481552
Nearby gene
RN7SKP147(-158657) ; LINC00320(+227037) ;
Downstream sequence
GTACTAGGAGGCTGTAGGCATAAATTGGTC
Junction sequence
AACACTGCCAGCTTTTGATTTTGTTTATAGGTACTAGGAGGCTGTAGGCATAAATTGGTC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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