Basic Information
VIS ID
TVIS10000261
Fusion event
HBV-chr22 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1729
Integrated sequence
CCACCGAATGTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCTGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAA| |GACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCA
Host Sequence
Chromosome
chr22
Cytoband
p11.2
Reference genome
GRCh38.p7
Start
11892442 (Hg38)
End
11892442 (Hg38)
Orient
+
Nearest miRNA
hsa-let-7a-3/Downstream/5871738;
Nearest TSS
ENST00000624155/Upstream/826024; ENST00000252835/Downstream/3396228;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/62349, chr22-CpG: 37/Downstream/81399
Nearby gene
LOC101928041(-685) ; LOC102723769(+4964) ;
Downstream sequence
GAGGCATACTTCAAAGACTGTTTGTTTAAA
Junction sequence
AAAAGTTAGGTATTTTCTTTATCTTTTATTGAGGCATACTTCAAAGACTGTTTGTTTAAA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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