Basic Information
VIS ID
TVIS10000264
Fusion event
HBV-chr22 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1810
Integrated sequence
CAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCA| |GCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACAT
Host Sequence
Chromosome
chr22
Cytoband
p11.1
Reference genome
GRCh38.p7
Start
14234431 (Hg38)
End
14234431 (Hg38)
Orient
-
Nearest miRNA
hsa-let-7a-3/Downstream/3529749;
Nearest TSS
ENST00000624155/Upstream/3168013; ENST00000252835/Downstream/1054239;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/1418797, chr22-CpG: 65/Downstream/1276372
Nearby gene
RNU6-1(+1039424) ;
Downstream sequence
GGCTGTAGGCATAAATTGGTCTGCGCACCA
Junction sequence
CCAAATTTCTCTGTAAAAAGAAAGGTTCAAGGCTGTAGGCATAAATTGGTCTGCGCACCA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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