Basic Information
VIS ID
TVIS10000266
Fusion event
HBV-LOC112268300 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1808
Integrated sequence
TTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCAC| |CAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGAC
Host Sequence
Chromosome
chr22
Cytoband
q11.21
Reference genome
GRCh38.p7
Start
21091453 (Hg38)
End
21091453 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC112268300
Nearest miRNA
hsa-mir-1286/Upstream/57181; hsa-let-7a-3/Downstream/561528;
Nearest TSS
ENST00000624155/Upstream/34923; ENST00000434730/Downstream/32998;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/45472, chr22-CpG: 28/Downstream/36555
Nearby gene
LRRC74B(-30925) ;
Downstream sequence
GAGGCTGTAGGCATAAATTGGTCTGCGCAC
Junction sequence
GCTGGGATTACAGGTGTGAGCCACCGTGCCGAGGCTGTAGGCATAAATTGGTCTGCGCAC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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