Basic Information
VIS ID
TVIS10000267
Fusion event
HBV-TMEM191C integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1788
Integrated sequence
CGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAG| |GCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTG
Host Sequence
Chromosome
chr22
Cytoband
q11.21
Reference genome
GRCh38.p7
Start
21465852 (Hg38)
End
21465852 (Hg38)
Orient
+
Location type
Intronic
Target gene
TMEM191C
Nearest miRNA
hsa-mir-1286/Upstream/431580; hsa-let-7a-3/Downstream/187129;
Nearest TSS
ENST00000624155/Upstream/23392; ENST00000545656/Downstream/571;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/19089, chr22-CpG: 201/Downstream/1430
Downstream sequence
CTACTACTTCTTAAAGGGTGAGAGGCGGGA
Junction sequence
ATTAAAGGTCTTTGTACTAGGAGGCTGTAGCTACTACTTCTTAAAGGGTGAGAGGCGGGA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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