ARHGAP8 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000270
Fusion event
HBV-ARHGAP8 integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1823
Integrated sequence
TTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACT| |TTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAA
Host Sequence
Chromosome
chr22
Cytoband
q13.31
Reference genome
GRCh38.p7
Start
44808539 (Hg38)
End
44808539 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
ARHGAP8
Nearest miRNA
hsa-mir-1281/Upstream/2885242; hsa-let-7a-3/Downstream/392415;
Nearest TSS
ENST00000624155/Upstream/6719; ENST00000469342/Downstream/51122;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/22196, chr22-CpG: 21/Downstream/107799
Downstream sequence
AATTGGTCTGCGCACCAGCACCATGCAACT
Junction sequence
GTCTGGTAGGGCGGAGGGTGGAGGGTGAGCAATTGGTCTGCGCACCAGCACCATGCAACT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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