Basic Information
VIS ID
TVIS10000271
Fusion event
HBV-PUDP integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1798
Integrated sequence
TGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTG| |GTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTG
Host Sequence
Chromosome
chrX
Cytoband
p22.31
Reference genome
GRCh38.p7
Start
6930292 (Hg38)
End
6930292 (Hg38)
Orient
-
Location type
Intronic
Target gene
PUDP
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-98-5p ; hsa-mir-346 ; hsa-mir-106a-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-3690-1/Upstream/546329; hsa-let-7f-2/Downstream/217568;
Nearest TSS
ENST00000429181/Upstream/208748; ENST00000217961/Downstream/217833;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/702427, chrX-CpG: 117/Downstream/217360
Nearby gene
PRPF31(-208748) ; PUDP(+118628) ;
Downstream sequence
TTTGTACTAGGAGGCTGTAGGCATAAATTG
Junction sequence
AGTCCTGCTGACCTCCTGTCTCATCCTTTGTTTGTACTAGGAGGCTGTAGGCATAAATTG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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