Basic Information
VIS ID
TVIS10000272
Fusion event
HBV-chrX integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1801
Integrated sequence
GGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTC| |TGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGG
Host Sequence
Chromosome
chrX
Cytoband
p11.21
Reference genome
GRCh38.p7
Start
57041053 (Hg38)
End
57041053 (Hg38)
Orient
-
Nearest miRNA
hsa-let-7f-2/Upstream/1589471; hsa-mir-105-1/Downstream/6744949;
Nearest TSS
ENST00000429181/Upstream/45226; ENST00000439622/Downstream/79537;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/45442, chrX-CpG: 32/Downstream/80193
Nearby gene
SPIN3(-45516) ; SPIN2B(+78629) ;
Downstream sequence
GTACTAGGAGGCTGTAGGCATAAATTGGTC
Junction sequence
AGCTCTCAGTGGCTGTGCCAAATCCAGCAGGTACTAGGAGGCTGTAGGCATAAATTGGTC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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