Basic Information
VIS ID
TVIS10000273
Fusion event
HBV-chrX integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1820
Integrated sequence
TTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCA| |ACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTAT
Host Sequence
Chromosome
chrX
Cytoband
q11.2
Reference genome
GRCh38.p7
Start
64419667 (Hg38)
End
64419667 (Hg38)
Orient
-
Nearest miRNA
hsa-let-7f-2/Upstream/633580; hsa-mir-105-1/Downstream/1599203;
Nearest TSS
ENST00000429181/Upstream/24236; ENST00000617377/Downstream/500460;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/24124, chrX-CpG: 78/Downstream/614861
Nearby gene
MTMR8(-24236) ; ZC4H2(+496135) ;
Downstream sequence
ATAAATTGGTCTGCGCACCAGCACCATGCA
Junction sequence
ACCAGAACAAGGACCCAAATTTTCCAGCTCATAAATTGGTCTGCGCACCAGCACCATGCA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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