Basic Information
VIS ID
TVIS10000276
Fusion event
HBV-chrX integration
Validated
Yes
Detection method
invPCR
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2018
PubMed ID
29437961
Virus Sequence
Virus name
HBV
Reference genome
U95551.1
End
1797
Integrated sequence
TTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATT| |GGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTT
Host Sequence
Chromosome
chrX
Cytoband
q27.3
Reference genome
GRCh38.p7
Start
143128127 (Hg38)
End
143128127 (Hg38)
Orient
-
Fragile sites / regions
FRAXA
Nearest miRNA
hsa-let-7f-2/Upstream/2201896; hsa-mir-105-1/Downstream/2864623;
Nearest TSS
ENST00000429181/Upstream/102195; ENST00000431432/Downstream/156850;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/1950907, chrX-CpG: 130/Downstream/505467
Nearby gene
RN7SKP81(-37450) ; RN7SKP149(+69121) ;
Downstream sequence
CTTTGTACTAGGAGGCTGTAGGCATAAATT
Junction sequence
GATTTTGGTGGGGACAGAGCCAAACCATATCTTTGTACTAGGAGGCTGTAGGCATAAATT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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