MYO3B _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000350
Fusion event
HBV-MYO3B integration
Validated
Yes
Detection method
invPCR+NAH
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2017
PubMed ID
28414318
Virus Sequence
Virus name
HBV
Subtype
A
Reference genome
X70185.1
Start
1623
End
1717
Integrated sequence
ACGCCCATCAGATCCTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCCTACTTCAAAGACTGT
Host Sequence
Chromosome
chr2
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
171450967/170594306 (Hg38)
End
171450816/170594457 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA2G
Target gene
MYO3B
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1-3p
Nearest miRNA
hsa-mir-128-1/Upstream/2011288; hsa-mir-10b/Downstream/4573176;
Nearest TSS
ENST00000437798/Upstream/185742; ENST00000487037/Downstream/100917;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/766187, chr2-CpG: 44/Downstream/117355
Target sequence
AGAGCTGGCTTCAGGTATTCCAGGGACTAAAATCATGTAACCTGTATCTTCTGTCTCCTGCTGTCCCCTGCAAGCCTAGAGTCTCTCCTCTCCTCATCTCTCATCTCCGCTCTCTTCTCCCTAGCTTCGCCATGCACTGACGATACTTTTT
Reference
Chauhan, R., et al. Initial sites of hepadnavirus integration into host genome in human hepatocytes and in the woodchuck model of hepatitis B-associated hepatocellular carcinoma. Oncogenesis ,2017,6(4): e317.
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