Basic Information
VIS ID
TVIS10000356
Fusion event
HBV-RNU7-147P integration
Validated
Yes
Detection method
invPCR+NAH
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2017
PubMed ID
28414318
Virus Sequence
Virus name
HBV
Subtype
A
Reference genome
X70185.1
Start
1276
End
1389
Integrated sequence
AACTCCTAGCCGCTTGTTTTGCTCGCAGCCGGTCTGGAGCAAAGCTCATCGGAACTGACAATTCTGTCGTCCTCTCGCGGAAATATACATCGTTTCCATGGCTGCTAGGCTGTA
Host Sequence
Chromosome
chr2
Cytoband
q33.1
Reference genome
GRCh37/hg19
Start
200085021/199220298 (Hg38)
End
200085080/199220357 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA2I
Target gene
RNU7-147P
Nearest miRNA
hsa-mir-10b/Upstream/10087187; hsa-mir-1244-1/Downstream/7562877;
Nearest TSS
ENST00000437798/Upstream/148507; ENST00000489557/Downstream/104953;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1414868, chr2-CpG: 315/Downstream/235422
Target sequence
GCTGTCCCAAATTCTAAATCAGTGGCTTTCAAATTTGACTGTACTTTAGAATCCCATGG
Reference
Chauhan, R., et al. Initial sites of hepadnavirus integration into host genome in human hepatocytes and in the woodchuck model of hepatitis B-associated hepatocellular carcinoma. Oncogenesis ,2017,6(4): e317.
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