Basic Information
VIS ID
TVIS10000359
Fusion event
HBV-RPS20P12 integration
Validated
Yes
Detection method
invPCR+NAH
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2017
PubMed ID
28414318
Virus Sequence
Virus name
HBV
Subtype
A
Reference genome
X70185.1
Start
1634
End
1826
Integrated sequence
ATCCTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCCTACTTCAAAGACTGTGTGTTTAAGGACTGGGAGGAGCTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTATTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCA
Host Sequence
Chromosome
chr2
Cytoband
q37.1
Reference genome
GRCh37/hg19
Start
235357695/234449051 (Hg38)
End
235357727/234449083 (Hg38)
Location type
Intronic
Target gene
RPS20P12
Nearest miRNA
hsa-mir-10b/Upstream/1898478; hsa-mir-149/Downstream/3061848;
Nearest TSS
ENST00000437798/Upstream/10723; ENST00000629370/Downstream/5512;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/352539, chr2-CpG: 184/Downstream/46775
Target sequence
ACCTCTGCACGTTTCGCTTCACCTCTGCACGATTC
Reference
Chauhan, R., et al. Initial sites of hepadnavirus integration into host genome in human hepatocytes and in the woodchuck model of hepatitis B-associated hepatocellular carcinoma. Oncogenesis ,2017,6(4): e317.
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