TMEM130 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000360
Fusion event
HBV-TMEM130 integration
Validated
Yes
Detection method
invPCR+NAH
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2017
PubMed ID
28414318
Virus Sequence
Virus name
HBV
Subtype
A
Reference genome
X70185.1
Start
1639
End
1829
Integrated sequence
GCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCCTACTTCAAAGACTGTGTGTTTAAGGACTGGGAGGAGCTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTATTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCT
Host Sequence
Chromosome
chr7
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
98457063/98859440 (Hg38)
End
98457081/98859458 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA7F
Target gene
TMEM130
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-574-5p ; hsa-mir-147a ; hsa-mir-6867-5p ; hsa-mir-644a ; hsa-mir-3911 ; hsa-mir-3650 ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-3177-5p
Nearest miRNA
hsa-mir-10525/Upstream/894959; hsa-mir-10399/Downstream/22192;
Nearest TSS
ENST00000635602/Upstream/11712; ENST00000417523/Downstream/7488;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/240993, chr7-CpG: 93/Downstream/9942
Target sequence
CCTGCTTCGTCTGTTCTG
Reference
Chauhan, R., et al. Initial sites of hepadnavirus integration into host genome in human hepatocytes and in the woodchuck model of hepatitis B-associated hepatocellular carcinoma. Oncogenesis ,2017,6(4): e317.
Curate