Basic Information
VIS ID
TVIS10000361
Fusion event
HBV-RNY1 integration
Validated
Yes
Detection method
invPCR+NAH
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2017
PubMed ID
28414318
Virus Sequence
Virus name
HBV
Subtype
A
Reference genome
X70185.1
Start
1370
End
1423
Integrated sequence
TCCATGGCTGCTAGGCTGTACTGCCAACTGGATCCTTCGCGGGACGTCCTTTGT
Host Sequence
Chromosome
chr7
Cytoband
q36.1
Reference genome
GRCh37/hg19
Start
60109931/60109931 (Hg38)
End
60109947/60109947 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA7J
Target gene
RNY1
Nearest miRNA
hsa-mir-1183/Upstream/2704841; hsa-mir-10399/Downstream/3511143;
Nearest TSS
ENST00000635602/Upstream/2659754; ENST00000418297/Downstream/2944484;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/2021758, chr7-CpG: 195/Downstream/845514
Target sequence
CGCTTCACCTCTGATG
Reference
Chauhan, R., et al. Initial sites of hepadnavirus integration into host genome in human hepatocytes and in the woodchuck model of hepatitis B-associated hepatocellular carcinoma. Oncogenesis ,2017,6(4): e317.
Curate