VISDB - VIS Detail

Expression analysis of TCGA samples

Basic Information

VIS ID

TVIS10000367

Fusion event

HBV-ANK3 integration

Validated

Yes

Detection method

invPCR+NAH

Data source

Curated

Sample type

Cell line

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2017

PubMed ID

28414318

Virus Sequence

Virus name

HBV

Subtype

A

Reference genome

X70185.1

Start

1647

End

1720

Integrated sequence

TCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCCTACTTCAAAGACTGTGTG

Host Sequence

Chromosome

chr10

Cytoband

q21.2

Reference genome

GRCh37/hg19

Start

111339527/109579769 (Hg38)

End

111339567/109579809 (Hg38)

Location type

Intronic

Fragile sites / regions

FRA10D ; FRA10A ; FRA10B

Target gene

ANK3

miRNAs that regulate target gene

hsa-mir-218-5p ; hsa-mir-8088 ; hsa-mir-598-5p ; hsa-mir-216b-3p ; hsa-mir-8485 ; hsa-mir-603 ; hsa-mir-503-5p ; hsa-mir-34a-5p

Nearest miRNA

hsa-mir-107/Upstream/5311364; hsa-mir-202/Downstream/1318281;

Nearest TSS

ENST00000439456/Upstream/869251; ENST00000459738/Downstream/291223;

Nearest CpG islands

None/Target, chr10-CpG: 68/Upstream/122444, chr10-CpG: 75/Downstream/343208

Target sequence

CAAAGACTGTTTACTTATAACTCTGTTGTCCCTGTTGTCC

Reference

Chauhan, R., et al. Initial sites of hepadnavirus integration into host genome in human hepatocytes and in the woodchuck model of hepatitis B-associated hepatocellular carcinoma. Oncogenesis ,2017,6(4): e317.