Basic Information
VIS ID
TVIS10000368
Fusion event
HBV-chr10:q11.21 integration
Validated
Yes
Detection method
invPCR+NAH
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2017
PubMed ID
28414318
Virus Sequence
Virus name
HBV
Subtype
A
Reference genome
X70185.1
Start
1371
End
1390
Integrated sequence
CCATGGCTGCTAGGCTGTAC
Host Sequence
Chromosome
chr10
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
42599732/42104284 (Hg38)
End
42599976/42104528 (Hg38)
Nearest miRNA
hsa-mir-1265/Upstream/6463032; hsa-mir-107/Downstream/893035;
Nearest TSS
ENST00000439456/Upstream/3651103; ENST00000442306/Downstream/80811;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/3161178, chr10-CpG: 184/Downstream/6505
Target sequence
ACGGATTGATGGATCGTCATCGAATGAATTGAATGCAATCATCGAATGGTCTYCRAAKGGAATCATCTTCAAATGGAATGGAATGGAATCATCGCATAGAATCGAATGGAATTATCATCGAATGGAATCGAATGGAATCAACATCAAACGGAAAAAAACGGAATTATCGAATGGAATCGAAGAGAATCATCGAATGGACCCGAATGAAATCATCTAATGGAATGGAATGGAATAATCCATGGAA
Reference
Chauhan, R., et al. Initial sites of hepadnavirus integration into host genome in human hepatocytes and in the woodchuck model of hepatitis B-associated hepatocellular carcinoma. Oncogenesis ,2017,6(4): e317.
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