Basic Information
VIS ID
TVIS10000372
Fusion event
HBV-chr11:q13.4 integration
Validated
Yes
Detection method
invPCR+NAH
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2017
PubMed ID
28414318
Virus Sequence
Virus name
HBV
Subtype
A
Reference genome
X70185.1
Start
1647
End
1818
Integrated sequence
TCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCCTACTTCAAAGACTGTGTGTTTAAGGACTGGGAGGAGCTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTATTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAA
Host Sequence
Chromosome
chr11
Cytoband
q13.4
Reference genome
GRCh37/hg19
Start
71034849/71323301 (Hg38)
End
71034347/71323803 (Hg38)
Fragile sites / regions
FRA11H
Nearest miRNA
hsa-mir-10392/Upstream/450933; hsa-let-7a-2/Downstream/149700;
Nearest TSS
ENST00000527297/Upstream/70724; ENST00000529369/Downstream/115156;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/70186, chr11-CpG: 32/Downstream/111593
Target sequence
AGCACCATGCACTGCCCTAGGGGCTGGTGACATAGCCCTGGATAGGCAAGGACCCTGCCCTCCTGGATGCCACCCTCCTGAGGACTGCACCCTCAACAAGCAGATACACAGGATGGCCTTGTAGATTCTGATGGGGCTTAGAAAGCCTCTACCTGCACAGTGAATGTGGGCTCGGGAAGATGGATTCACTGCTGTGGCTGAGCAGCCCCCTGTCCCCCAGGCTTCTCCGATCCCTCCTTACTTGGGGCTCCACCTGCCTTCAGGCCTCCTGTGGCAGCCGGTGGCCCTGACTCTGACCCTGGCCCTTTGGATGGAGCCTCCTGGCACTGGTTTCCTCCCTAGGTTCCCACAGAACTGGCTCTCCCTAGCTCTTCCGCCTCTGTCCTTGGCTTTGGCATCCCCAGCATTTACCTCCCTGGGCCTGGGCACTGGGTGTGTTCCTCAGCCTCCGGCAACAGCAGCCTCCTGTTTGACCACTGACACAGACACTTAAGACATGGAG
Reference
Chauhan, R., et al. Initial sites of hepadnavirus integration into host genome in human hepatocytes and in the woodchuck model of hepatitis B-associated hepatocellular carcinoma. Oncogenesis ,2017,6(4): e317.
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