VISDB - VIS Detail

Expression analysis of TCGA samples

Basic Information

VIS ID

TVIS10000379

Fusion event

HBV-FGF14 integration

Validated

Yes

Detection method

invPCR+NAH

Data source

Curated

Sample type

Cell line

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2017

PubMed ID

28414318

Virus Sequence

Virus name

HBV

Subtype

A

Reference genome

X70185.1

Start

1662

End

1603

Integrated sequence

TTGCATGGAGACCACCGTGAACGCCCATCAGATCCTGCCCAAGGTCTTACATAAGAGGAC

Host Sequence

Chromosome

chr13

Cytoband

q33.1

Reference genome

GRCh37/hg19

Start

102521074/101868724 (Hg38)

End

102521122/101868772 (Hg38)

Location type

Intronic

Target gene

FGF14

miRNAs that regulate target gene

hsa-mir-574-5p ; hsa-mir-4455 ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-511-3p ; hsa-mir-5010-3p ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-8068

Nearest miRNA

hsa-mir-1297/Upstream/2225575; hsa-mir-1267/Downstream/98870;

Nearest TSS

ENST00000623511/Upstream/151160; ENST00000444686/Downstream/6522;

Nearest CpG islands

None/Target, chr13-CpG: 551/Upstream/414587, chr13-CpG: 120/Downstream/47303

Target sequence

ATAGCCGTGAATGAATGGAGAAGGTTACCTCTACCCATGAGAACTTTT

Reference

Chauhan, R., et al. Initial sites of hepadnavirus integration into host genome in human hepatocytes and in the woodchuck model of hepatitis B-associated hepatocellular carcinoma. Oncogenesis ,2017,6(4): e317.