Basic Information
VIS ID
TVIS10000393
Fusion event
HBV-chr15:q11.2 integration
Validated
Yes
Detection method
invPCR+NAH
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2017
PubMed ID
28414318
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
AB033556.1
Start
1645
End
1764
Integrated sequence
GGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACAACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGT
Host Sequence
Chromosome
chr15
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
21340909/21135580 (Hg38)
End
21341183/21135854 (Hg38)
Nearest miRNA
hsa-mir-3118-2/Upstream/195247; hsa-mir-10393/Downstream/270531;
Nearest TSS
ENST00000557528/Upstream/5485; ENST00000630916/Downstream/189387;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/53995, chr15-CpG: 50/Downstream/39009
Target sequence
AACACTTTCACACTGTTGGTGGGACTGTAAACTAGTTCAACCACTGTGGAAGACAGTGTGGCCATTCCTCAGGGATCTAGAACTAGAAATACCATTTGACCCAGCCATCCCACTACTGGGTATATACCCAAAGGATTATAAATTGTGCTGCTATAAAGACACATGCACATGTATGTTTATTGCGGCACTATTCACAATAGCAAAGACTTGGAACCAACCCAAATGTCCAACAATGATAGACTGGATGAAGAAAATGTGGCACATATACACCATG
Reference
Chauhan, R., et al. Initial sites of hepadnavirus integration into host genome in human hepatocytes and in the woodchuck model of hepatitis B-associated hepatocellular carcinoma. Oncogenesis ,2017,6(4): e317.
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