Basic Information
VIS ID
TVIS10000394
Fusion event
HBV-chr10:q21.3 integration
Validated
Yes
Detection method
invPCR+NAH
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2017
PubMed ID
28414318
Virus Sequence
Virus name
HBV
Subtype
E
Reference genome
X75657.1
Start
1641
End
1778
Integrated sequence
CCAAGGTCTTACATAAGAGGACTCTTGGACTCTCTGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTCGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAG
Host Sequence
Chromosome
chr10
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
146/146 (Hg38)
End
417/417 (Hg38)
Nearest miRNA
hsa-mir-107/Downstream/641272;
Nearest TSS
ENST00000439456/Downstream/14187;
Nearest CpG islands
None/Target, None/Upstream, chr10-CpG: 68/Downstream/10938
Target sequence
YGWMRTGGTTGYYARGAWKARGGCAGCACAAAGGGAGCCAAGAAGAAAGTGCTTGATCCATTTTCTAAGAAAGATTTGTATTACGTGAAAGCATCTGCCATGTTCAATATAAAAAATATTGGGAAGACACTAGTCACCASAACCCAAGGAACCATAATTGAATCTGATGGCCTCAAGGGTCGTGTATTTGAAGTGAGTCTTGCTGATATGCAGAATGATAAAGTTGCATTTAGAAAATTCAGCTGATTACTGAAGATGTTCAGGGGAATGA
Reference
Chauhan, R., et al. Initial sites of hepadnavirus integration into host genome in human hepatocytes and in the woodchuck model of hepatitis B-associated hepatocellular carcinoma. Oncogenesis ,2017,6(4): e317.
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