Basic Information
VIS ID
TVIS10000399
Fusion event
HBV-LOC105371200 integration
Validated
Yes
Detection method
invPCR+NAH
Data source
Curated
Sample type
Cell line
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2017
PubMed ID
28414318
Virus Sequence
Virus name
HBV
Subtype
E
Reference genome
X75657.1
Start
1647
End
1826
Integrated sequence
TCTTACATAAGAGGACTCTTGGACTCTCTGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTCGGGGGAGGAGATTAGATTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCA
Host Sequence
Chromosome
chr16
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
34456932/35222561 (Hg38)
End
34456967/35222596 (Hg38)
Location type
Intronic
Target gene
LOC105371200
Nearest miRNA
hsa-mir-1225/Upstream/1058888; hsa-mir-11401/Downstream/15070020;
Nearest TSS
ENST00000527434/Upstream/14602; ENST00000561756/Downstream/140816;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/14558, chr16-CpG: 38/Downstream/129750
Target sequence
GATTCCATTCAATGATGATTGCATTCGAGTCCATG
Reference
Chauhan, R., et al. Initial sites of hepadnavirus integration into host genome in human hepatocytes and in the woodchuck model of hepatitis B-associated hepatocellular carcinoma. Oncogenesis ,2017,6(4): e317.
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