Basic Information
VIS ID
TVIS10000403
Fusion event
HBV-SLF2 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2015
PubMed ID
25901726
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
Not given
End
1869
Host Sequence
Chromosome
chr10
Cytoband
q24.32
Reference genome
GRCh37/hg19
Start
102723937/102723937 (Hg38)
End
102723937/102723937 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
SLF2
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-107/Upstream/287353; hsa-mir-1307/Downstream/670316;
Nearest TSS
ENST00000439456/Upstream/9278; ENST00000602868/Downstream/2563;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/8983, chr10-CpG: 28/Downstream/130306
Downstream sequence
gtagagagggagaaatgttcattgcacaga
Junction sequence
CCCAAAGCCACCCAAGGCACAGCTTGGAGGgtagagagggagaaatgttcattgcacaga
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Dong, H., et al. Identification of HBV-MLL4 Integration and Its Molecular Basis in Chinese Hepatocellular Carcinoma. PLoS One,2015, 10(4): e0123175.
Curate