GTF2I _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000405
Fusion event
HBV-GTF2I integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2015
PubMed ID
25901726
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
Not given
End
464
Host Sequence
Chromosome
chr7
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
74125369/74711038 (Hg38)
End
74125369/74711038 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA7J
Target gene
GTF2I
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-21-5p ; hsa-mir-1229-3p ; hsa-mir-10a-3p ; hsa-mir-484 ; hsa-mir-23b-3p ; hsa-mir-99a-5p ; hsa-let-7e-5p ; hsa-let-7a-5p ; hsa-mir-335-3p ; hsa-mir-1305 ; hsa-mir-607 ; hsa-mir-3671 ; hsa-mir-580-5p ; hsa-mir-1252-3p ; hsa-mir-3646 ; hsa-mir-3121-3p
Nearest miRNA
hsa-mir-10525/Upstream/115012; hsa-mir-10399/Downstream/1204159;
Nearest TSS
ENST00000635602/Upstream/5861; ENST00000484840/Downstream/5574;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/52286, chr7-CpG: 124/Downstream/76951
Upstream sequence
AGAAAGGCCTTGTAAGTTGGCGAGAAAGTG
Junction sequence
AGAAAGGCCTTGTAAGTTGGCGAGAAAGTGtcacatgcgatctacattaatatcaagtct
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Dong, H., et al. Identification of HBV-MLL4 Integration and Its Molecular Basis in Chinese Hepatocellular Carcinoma. PLoS One,2015, 10(4): e0123175.
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