MED13L _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000430
Fusion event
HBV-MED13L integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2015
PubMed ID
25901726
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
Not given
End
2449
Host Sequence
Chromosome
chr12
Cytoband
q24.21
Reference genome
GRCh37/hg19
Start
116534555/116096750 (Hg38)
End
116534555/116096750 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12E ; FRA12C
Target gene
MED13L
miRNAs that regulate target gene
hsa-mir-590-3p ; hsa-mir-98-5p ; hsa-mir-93-5p ; hsa-mir-615-3p ; hsa-mir-18a-3p ; hsa-mir-328-3p ; hsa-mir-23b-3p ; hsa-let-7e-5p ; hsa-let-7a-5p ; hsa-mir-676-5p ; hsa-mir-582-3p
Nearest miRNA
hsa-let-7i/Upstream/2805142; hsa-mir-1178/Downstream/51810;
Nearest TSS
ENST00000382841/Upstream/87605; ENST00000548506/Downstream/180009;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/179368, chr12-CpG: 196/Downstream/179900
Downstream sequence
gcctaatggataagaacttcgttaggattg
Junction sequence
AGAAGATCTCAATCTCGGGAATCTCAATGTgcctaatggataagaacttcgttaggattg
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Dong, H., et al. Identification of HBV-MLL4 Integration and Its Molecular Basis in Chinese Hepatocellular Carcinoma. PLoS One,2015, 10(4): e0123175.
Curate