hsa-mir-892b _LIHC.png
CCNE1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000441
Fusion event
AAV2-CCNE1 integration
Validated
Yes
Fusion type
Delete and Reverse Insert
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2015
PubMed ID
26301494
Virus Sequence
Virus name
AAV2
Reference genome
AF043303.1
Start
4599
End
4379
Orient
-
Integrated sequence
TGGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTCGTTTCAGTTGAACTTTGGTCTCTGCGTATTTCTTTCTTATCTAGTTTCCATGGCTACGTAGATAAGTAGCATGGCGGGTTAATCATTAACTACAAGGAACCCCTAGTGATGGAGTTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGGGC
Host Sequence
Chromosome
chr19
Cytoband
q12
Reference genome
GRCh37/hg19
Start
30287313/29796406 (Hg38)
End
30287316/29796409 (Hg38)
Orient
+
Location type
Intronic
Target gene
CCNE1
miRNAs that regulate target gene
hsa-mir-15b-5p ; hsa-mir-503-5p ; hsa-mir-424-5p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-107 ; hsa-mir-185-5p ; hsa-mir-103a-3p ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-16-1-3p ; hsa-mir-195-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-151a-3p ; hsa-mir-342-5p ; hsa-mir-125b-5p ; hsa-mir-92a-3p ; hsa-mir-383-3p ; hsa-mir-497-5p ; hsa-mir-4524a-5p ; hsa-mir-4694-3p ; hsa-mir-4524b-5p ; hsa-mir-6838-5p ; hsa-mir-7-5p ; hsa-mir-4477a ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-5191 ; hsa-mir-646 ; hsa-mir-25-5p ; hsa-mir-30c-2-3p ; hsa-mir-144-5p ; hsa-mir-892b
Nearest miRNA
hsa-mir-10395/Upstream/9397052; hsa-let-7e/Downstream/5326291;
Nearest TSS
ENST00000633603/Upstream/80617; ENST00000586912/Downstream/15489;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/71719, chr19-CpG: 137/Downstream/14979
Nearest cancer related gene
CCNE1(OG, No orient, 0)
Upstream sequence
TGCCTGCTCCCCCTTCCAGGCCCTCCTGCACACATCTTTCACTCAAACCTGTGAAATATGGAGCGCCTCCCACGGGCCTCTGTGCGGCTTCCTTCTGCCAGGAAAAGGGCCCC
Downstream sequence
CCAACAAGTAAACAAATGTCCAATTACAAAATGTCTCAGGTGCTGTGGAGAATAAAAATATGGAGCTTAATTAAAAGGAGGAAGCATTTATTCCAGCATGTGAGCTGTATTTCAAGGCAACCAAATAGC
Target sequence
GA
Junction sequence
TGCCTGCTCCCCCTTCCAGGCCCTCCTGCACACATCTTTCACTCAAACCTGTGAAATATGGAGCGCCTCCCACGGGCCTCTGTGCGGCTTCCTTCTGCCAGGAAAAGGGCCCCCCCCGGCCTCAGTGAGCGAGCGAGCGCGCAGAGAGGGAGTGGCCAACTCCATCACTAGGGGTTCCTTATAGTTAATGATTAACCCGCCATGGTACTTATCTACGTAGCCATGGAAACTAGATAAGAAAGAAGTACGCAGAGACCAAAGTTCAACTGAAACGAATTACACGGTTTATTGATTAACAAGCAATTACAGATTACGAGTCAGGTATCTGGTGCCAACAAGTAAACAAATGTCCAATTACAAAATGTCTCAGGTGCTGTGGAGAATAAAAATATGGAGCTTAATTAAAAGGAGGAAGCATTTATTCCAGCATGTGAGCTGTATTTCAAGGCAACCAAATAGC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Nault, J. C., et al. Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas. Nat Genet ,2015,47(10): 1187-1193.
Curate