hsa-mir-892b _LIHC.png
CCNE1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000442
Fusion event
AAV2-CCNE1 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2015
PubMed ID
26301494
Virus Sequence
Virus name
AAV2
Reference genome
AF043303.1
Start
4340
End
4614
Orient
+
Integrated sequence
TGTGGACACTAATGGCGTGTATTCAGAGCCTCGCCCCATTGGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTCGTTTCAGTTGAACTTTGGTCTCTGCGTATTTCTTTCTTATCTAGTTTCCATGGCTACGTAGATAAGTAGCATGGCGGGTTAATCATTAACTACAAGGAACCCCTAGTGATGGAGTTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGC
Host Sequence
Chromosome
chr19
Cytoband
q12
Reference genome
GRCh37/hg19
Start
30303035/29812128 (Hg38)
End
30303053/29812146 (Hg38)
Orient
+
Location type
Intronic
Target gene
CCNE1
miRNAs that regulate target gene
hsa-mir-15b-5p ; hsa-mir-503-5p ; hsa-mir-424-5p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-107 ; hsa-mir-185-5p ; hsa-mir-103a-3p ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-16-1-3p ; hsa-mir-195-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-151a-3p ; hsa-mir-342-5p ; hsa-mir-125b-5p ; hsa-mir-92a-3p ; hsa-mir-383-3p ; hsa-mir-497-5p ; hsa-mir-4524a-5p ; hsa-mir-4694-3p ; hsa-mir-4524b-5p ; hsa-mir-6838-5p ; hsa-mir-7-5p ; hsa-mir-4477a ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-5191 ; hsa-mir-646 ; hsa-mir-25-5p ; hsa-mir-30c-2-3p ; hsa-mir-144-5p ; hsa-mir-892b
Nearest miRNA
hsa-mir-10395/Upstream/9412774; hsa-let-7e/Downstream/5310554;
Nearest TSS
ENST00000633603/Upstream/124; ENST00000586912/Downstream/508;
Nearest CpG islands
chr19-CpG: 137/Target, None/Upstream, None/Downstream
Nearest cancer related gene
CCNE1(OG, No orient, 0)
Upstream sequence
CAGGAGCAGCCGGCGCGGCCGCCAGCGCGGTGTAGGGGGCAGGCGCGGATCCCGCCACCGCCGCGCGCTCGGCCCGCCGACTCCCGGCGCCGCCGCCGCCACTGCCGTCGCCGCCGCCGCCTGCCGGGACTGGAGCGC
Downstream sequence
CACTCCGACCCTGGTGAGTCTACTGCCGCGGGCTGCGGACAGGGACTCCTGGGGCCCAGACCGCGCCGGGGAGCTGGGTGGGGGCGGGGTGCGGCCGGGTCGCGGGTCCCCGGGCGGCGTCGCGGGGCGCCCGGG
Target sequence
CCGTCCGCCGCGGACAA
Junction sequence
CAGGAGCAGCCGGCGCGGCCGCCAGCGCGGTGTAGGGGGCAGGCGCGGATCCCGCCACCGCCGCGCGCTCGGCCCGCCGACTCCCGGCGCCGCCGCCGCCACTGCCGTCGCCGCCGCCGCCTGCCGGGACTGGAGCGCGTCTGTGGACACTAATGGTGTGTATTCAGAGCCTCGCCCCATTGGCACCAGATACCTGACTCGTAATCTGTAATTGCTTGTTAATCAATAAACCGTTTAATTCGTTTCAGTTGAACTTTGGTCTTTGCGTACTTCTTTCTTATCTAGTTTCCATGGCTACGTAGATAAGTAGCATGGCGGGTTATTCATTAACTCTAAGGAACCCCTAGTGATGGAGTTGGCCACTCCCTCTCTGCGCGCTCGCTCGCTCACTGAGGCCGCCCGGGCAAAGCCCGGGCGTCGGGCGACCTTTGGTCGCCACTCCGACCCTGGTGAGTCTACTGCCGCGGGCTGCGGACAGGGACTCCTGGGGCCCAGACCGCGCCGGGGAGCTGGGTGGGGGCGGGGTGCGGCCGGGTCGCGGGTCCCCGGGCGGCGTCGCGGGGCGCCCGGG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Nault, J. C., et al. Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas. Nat Genet ,2015,47(10): 1187-1193.
Curate