Basic Information
VIS ID
TVIS10000448
Fusion event
HBV-LOC110806263 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr5
Cytoband
p15.33
Reference genome
GRCh37/hg19
Start
1296624/1296509 (Hg38)
End
1296624/1296509 (Hg38)
Location type
Intronic
Target gene
LOC110806263
Nearest miRNA
hsa-mir-4635/Upstream/233535; hsa-mir-10397/Downstream/12801;
Nearest TSS
ENST00000502646/Upstream/1440; ENST00000605200/Downstream/25320;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/654, chr5-CpG: 18/Downstream/38453
Nearby gene
TERT(-1462) ; MIR4457(+12801) ;
Downstream sequence
CAGTGTAAGCTACAACTTAACTTTTGTTGGAACAAATTTTCCAAACCGCCCCTTTGCCCTAGTGGCAGAGACAATTCACAAACACAGCCCTTTAAAAAGGCTTAGGGATCACTAGGGGGATTTCTAGAAGAGCGACCTGTAATCCTAAGTATTTACAAGACGAGGCTAACCTCCAGCGAGCGTGACAGCCCAGGGAGGGTGCGAGGCCTGTTCAAATGCT
Junction sequence
CCGAGACGGGTCGTCCGCGGGATTCAGCGCCGACGGGACGTAGACAGTGTAAGCTACAACTTAACTTTTGTTGGAACAAATTTTCCAAACCGCCCCTTTGCCCTAGTGGCAGAGACAATTCACAAACACAGCCCTTTAAAAAGGCTTAGGGATCACTAGGGGGATTTCTAGAAGAGCGACCTGTAATCCTAAGTATTTACAAGACGAGGCTAACCTCCAGCGAGCGTGACAGCCCAGGGAGGGTGCGAGGCCTGTTCAAATGCT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
Curate