AHRR _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10000460
Fusion event
HBV-AHRR integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr5
Cytoband
p15.33
Reference genome
GRCh37/hg19
Start
425784/425669 (Hg38)
End
425784/425669 (Hg38)
Location type
Intronic
Target gene
AHRR
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-26a-5p ; hsa-mir-18a-5p ; hsa-mir-125b-5p
Nearest miRNA
hsa-mir-10397/Downstream/637227;
Nearest TSS
ENST00000502646/Upstream/3292; ENST00000511487/Downstream/2249;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/4033, chr5-CpG: 76/Downstream/17036
Nearest cancer related gene
AHRR(TSG, No orient, 0)
Downstream sequence
GTGCAGCCACTGGAATATAGTTTAAAATGGAATTGT
Junction sequence
AACCACAATAGTTGTCTGATTTTTAGGCCCATGTTAACATTGACATAGCTGACTATCAATTCCCTGGATGCTGGGTCTTCCAAATTACTTCCCACCCAGGTGGCCAAATTCATCAACTCACCCAACACAGAATTGCTTGCCTGAGTGCAGCCACTGGAATATAGTTTAAAATGGAATTGT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
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