Basic Information
VIS ID
TVIS10000507
Fusion event
HBV-chr11 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Perfect
Reported year
2016
PubMed ID
27703150
Virus Sequence
Virus name
HBV
Reference genome
AF090842.1;AB033554.1;AB014381.1;M32138.1;AB032431.1;AB036910.1;AB064310;AY090454.1
Host Sequence
Chromosome
chr11
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
69479002/69664234 (Hg38)
End
69479002/69664234 (Hg38)
Fragile sites / regions
FRA11H ; FRA11A
Nearest miRNA
hsa-mir-10392/Upstream/580976; hsa-let-7a-2/Downstream/619721;
Nearest TSS
ENST00000527297/Upstream/5804; ENST00000534086/Downstream/3778;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/9850, chr11-CpG: 58/Downstream/10752
Nearby gene
CCND1(-9760) ; LTO1(+1330) ;
Nearest cancer related gene
CCND1(OG, -9760) ;
Upstream sequence
GACGCTGCGTCTTATAGAGATGAGGACACACACAGTGGAAAGACGTAAGGACACGGGGGGAAGGTAGCTGTCTGCAAGGCAAGGAGAGAGGCCTCAGGAGGGAGCAGCCCTGTGACACCT
Target sequence
TTAGTtgccccacatctctcttgttagtaagtaag
Junction sequence
GACGCTGCGTCTTATAGAGATGAGGACACACACAGTGGAAAGACGTAAGGACACGGGGGGAAGGTAGCTGTCTGCAAGGCAAGGAGAGAGGCCTCAGGAGGGAGCAGCCCTGTGACACCTGAAGGGGACGGTAGAGTCCCAAACGGCCCCGAGACGGGTCGTCCGCGGGATTCAGCGCCGACGGGACGTAGACAAAGGACGTCCCGCGCAGGATCCAGTTGGCAGCACACCCTAGCAGCCATGGAAAGGAGGTGTATTTCCGAGAGAGGACAACAGAGTTGTCAGTTCCGATAAGTTTCGCTCCAGACCGGCTGCGAGCAAAACAAGCTGCTAGGAGTTCCGCAGTATGACCGGGCAGAGGA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Zhao, L. H., et al.Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun ,2016,7: 12992.
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